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・ L-stability
・ L-statistic
・ L-system
・ L-theory
・ L-threo-3-Methylaspartate
・ L-threonate 3-dehydrogenase
・ L-threonine 3-dehydrogenase
・ L-threonine dehydrogenase
・ L-threonine kinase
・ L-Tido
・ L-Tronics
・ L-tryptophan—pyruvate aminotransferase
・ L-type
・ L-type asteroid
・ L-type calcium channel
L-type lectin domain
・ L-value
・ L-vocalization
・ L-xylose 1-dehydrogenase
・ L-xylulokinase
・ L-xylulose reductase
・ L. A. and Adelheid Machemehl House
・ L. A. Calkins
・ L. A. Cammiade
・ L. A. Dunton (schooner)
・ L. A. Fabunmi
・ L. A. Govindaraghava Aiyar
・ L. A. Mayer Institute for Islamic Art
・ L. A. Micheloni
・ L. A. Pittenger


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L-type lectin domain : ウィキペディア英語版
L-type lectin domain

In molecular biology the L-like lectin domain is a protein domain found in lectins which are similar to the leguminous plant lectins.
Lectins are structurally diverse proteins that bind to specific carbohydrates. This family includes the VIP36 and ERGIC-53 lectins. Although proteins containging this domain were originally identified as a family of animal lectins, there are also yeast representatives.〔
ERGIC-53 is a 53kDa protein, localised to the intermediate region between the endoplasmic reticulum and the Golgi apparatus (ER-Golgi-Intermediate Compartment, ERGIC). It was identified as a calcium-dependent, mannose-specific lectin. Its dysfunction has been associated with combined factors V and VIII deficiency, suggesting an important and substrate-specific role for ERGIC-53 in the glycoprotein-secreting pathway.〔
The L-like lectin domain has an overall globular shape composed of a beta-sandwich of two major twisted antiparallel beta-sheets. The beta-sandwich comprises a major concave beta-sheet and a minor convex beta-sheet, in a variation of the jelly roll fold.
==References==


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